Table 5.
Differentiation markers in non-grafted, untreated xenografts and diethylstilbestrol-treated human fetal vagina
| Non-grafted* | Grafted control-No treatment | Grafted-DES Strat. Epi. | Grafted-DES Adenosis | Control/DES figures | |
|---|---|---|---|---|---|
| Epithelium | |||||
| KRT7/8 | + | + (4/4) | + (3/4) | + (2/2) | 4A-C, F/13A-B |
| KRT19 | + | + (4/4) | + (4/4) | + (2/2) | 5A, C/14A-B |
| KRT6 | + | + (4/4) | + (4/4) | − (2/2) | 6D/15A-B |
| KRT14 | − | − (3/4) + (1/1) | + (2/4) | − (2/2) | 7A-B/16A-B |
| KRT10 | − | − (4/4) | − (4/4) | − (2/2) | NS/NS |
| RUNX1 | − | + (4/4) | + (4/4) | − (2/2) | 9B, F/18A-B |
| TP63 | − | + (4/4) | + (4/4) | − (2/2) | 8D-E/17A-C |
| ESR1 | + | − (3/4) MD + (1/1) UGS | + (3/4) | + (2/2) | 3A/11D |
| PGR | − | − (4/4) | + (4/4) | + (2/2) | NS/12B |
| AR | + | − (4/4), | − (4/4) | + (2/2) | |
| Mesenchyme | |||||
| α-actin | + | + (3/3) | + (4/4) | + (2/2) | 20A/20B |
| ISL | − | +(2/3) | + (4/4) | + (2/2) | 10A/19A |
| HOXA11 | − | − (3/3) | − (4/4) | − (2/2) | 10B/NS |
| ESR1 | + | + (4/4) | + (3/4) | + (2/2) | 3A/11D |
| PGR | − | − (4/4) | − (2/3) | − (2/2) | NS/12B |
| AR | + (4/4) | + (4/4) | + (2/2) | NS/NS |