Table IV.
Univariate and multivariate Cox regression analysis of overall survival in the TARGET.
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Variable | P-value | HR | 95% CI | P-value | HR | 95% CI |
| Sex (male vs. female) | 0.0550 | 1.7240 | 0.9880–3.0090 | 0.0710 | 1.7490 | 0.9530–3.2090 |
| Ethnicity (black vs. white) | 0.0380 | 2.0110 | 1.0410–3.8870 | 0.1590 | 1.6450 | 0.8230–3.2890 |
| Age (>2 vs. <2 years) | 0.2070 | 1.8140 | 0.7200–3.5760 | 0.7330 | 1.2050 | 0.4130–3.5130 |
| NMTS Stage (III–V vs. I–II) | <0.0001 | 3.3020 | 1.8190–3.9940 | 0.0030 | 2.8570 | 1.4370–3.6840 |
| Histology (DAWT vs. FHWT) | 0.8380 | 1.0640 | 0.5870–3.9280 | 0.9350 | 0.9680 | 0.4470–3.0990 |
| MYCNOS | 0.0030 | 1.4510 | 1.1330–3.8570 | 0.0420 | 1.3550 | 1.1060–3.8150 |
| DLEU2 | 0.0550 | 1.3500 | 0.9940–3.8360 | 0.8560 | 1.0600 | 0.7220–3.4840 |
| C8orf31 | 0.0500 | 0.7580 | 0.5740–3.0010 | 0.7590 | 0.9530 | 0.6980–3.2990 |
HR, hazard ratio; CI, confidence interval; NMTS, National Wilms Tumor Study; DAWT, diffuse anaplastic histology Wilms tumor; FHWT, favorable histology Wilms tumor; MYCNOS, MYCN opposite strand; DLEU2, deleted in lymphocytic leukemia 2; C8orf31, chromosome 8 open reading frame 31.