Table 2:
Outcome Studies on Permanent His-bundle Pacing
| Author | Trial Design | Follow-up | Number of Patients | Success Rate | Important Characteristics | Outcome(s) | |
|---|---|---|---|---|---|---|---|
| Sharma et al.26 | Prospective | 2 years | 94 | 80% | Indication for pacing | • | Improvement in HFH, no significant improvement in mortality or AF |
| Deshmukh et al.34 | Prospective | 3 years | 18 | 66% | Chronic AF, LVEF < 40%, QRS duration <120 ms, prior AVN ablation | • | Improvement in left ventricular dimensions, NYHA FC, and LVEF |
| Occhetta et al.35 | Randomized, 6-month crossover study of RVP versus HBP | 1 year | 16 | 94% | Chronic AF, prior AVN ablation | • | Improvement in NYHA FC, 6MWT, QOL, and hemodynamics |
| Kronborg et al.36 | Randomized, 12-month crossover study of HBP versus RVSP | 2 years | 38 | 84% | AVB, baseline narrow QRS, LVEF > 40% | • | Improvement in LVEF; no significant improvement in NYHA FC, 6MWT, or QOL |
| Pastore et al.37 | Retrospective study; 31% HBP, 29% RVSP, and 39% RVAP | 1 year | 477 | N/A | Complete AVB, paroxysmal AF: 26% HBP and 16% RVSP/RVAP | • | HBP was associated with a lower risk of persistent/permanent AF occurrence in comparison with both RVAP and RVSP |
| Vijayaraman et al.38 | Prospective case series | 70 months | 20 | N/A | His-Purkinje conduction, QRS duration, NYHA FC, and LVEF | • | His conduction and QRS duration remained stable; LVEF and left ventricular dimensions showed non-significant improvement in long term follow-up |
HFH: heart failure hospitalizations; AF: atrial fibrillation; NYHA FC: New York Heart Association functional class; LVEF: left ventricular ejection fraction; RVP: right ventricular pacing; HBP: His-bundle pacing; AVN: atrioventricular node; 6MWT: six-minute walk test; QOL: quality of life; RVSP: right ventricular septal pacing; AVB: atrioventricular block; RVAP: right ventricular apical pacing.