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Proposed role of HPSE in EGFR signaling in brain metastatic breast cancer cells. Extracellular EGF binds to both EGFR and HER2 receptors on the cell membrane. Activation of these receptors results in the nucleolar translocation of HPSE, where it can activate Topo1. HPSE may cleave HS bound to Topo1, but this is yet to be confirmed. Topo1 proceeds to drive cell proliferation
