Table 3.

Disposition of [¹⁴C]DMAE in male and female Wistar Han rats 24 or 72 h following a single gavage or intravenous administration.

% Dose Recovereda
Tissue	Male, Gavage 10 mg/kg	Male, Gavage 100 mg/kg	Male, Gavage 500 mg/kg	Male, IV 10 mg/kg	Female, Gavage 500 mg/kg	Male, Gavageb 500 mg/kg	Male, Gavagec 500 mg/kg
Urined	57.0 ± 4.10	58.6 ± 5.10	62.1 ± 1.50	39.2 ± 7.80	63.5 ± 1.80	68.6 ± 2.00	60.4 ± 3.80
Feces	0.206 ± 0.242	0.302 ± 0.061	0.518 ± 0.472	0.330 ± 0.092	0.549 ± 0.147	1.11 ± 1.01	0.538 ± 0.335
VOCs	0.153 ± 0.037	---	0.198 ± 0.038	0.230 ± 0.029	0.818 ± 0.456	---	0.220 ± 0.047
CO2	3.67 ± 0.440	4.84 ± 0.700	4.78 ± 0.810	3.52 ± 0.780	6.09 ± 0.810	7.94 ± 1.72e	2.94 ± 0.230
Tissues and GI Tractf	33.9 ± 2.20	30.1 ± 3.80	24.3 ± 2.10	38.5 ± 2.30	27.4 ± 1.40	14.5 ± 1.20	34.1 ± 1.80
Total Recovered	94.9 ± 3.20	93.9 ± 2.90	92.1 ± 1.90	81.8 ± 7.10	98.4 ± 0.800	92.0 ± 2.20	98.3 ± 3.50

^aMean ± SD, N= 3 animals;

^b72 h, N = 5

^cSprague Dawley rats

^dIncludes urine present in the bladder at study termination

^eCollection was terminated at 39 h

^fIncludes contents