Table 5.

Disposition of [¹⁴C]DMAE in male and female B6C3F1 mice 24 or 72 h following a single gavage administration.

% Dose Recovereda
Tissue	Female 10 mg/kg	Female 100 mg/kg	Female 500 mg/kg	Male 500 mg/kg	Femaleb 500 mg/kg
Urinec	15.8 ± 4.00	17.9 ± 3.90	43.4 ± 11.5	27.1 ± 20.0	53.8 ± 3.90
Feces	1.94 ±0.490	1.10 ± 0.410	0.713 ± 0.273	13.7 ± 14.9	2.24 ± 1.31
VOCs	1.66 ± 0.340	1.27 ± 0.160	1.51 ± 0.210	1.75 ± 0.319	1.08 ± 0.190
CO2	22.3 ± 3.68	15.5 ± 0.600	13.2 ± 1.80	17.8 ± 1.10	21.0 ± 2.20
Tissues and GI Tractd	57.6 ± 3.00	44.5 ± 1.70	38.4 ± 16.1	31.8 ± 1.50	19.0 ± 3.70
Total Recovered	99.3 ± 1.60	81.6 ± 4.40	97.1 ± 15.2	92.1 ± 13.6	97.2 ± 6.40

^aMean ± SD for 3 animals;

^b72 h, N = 4

^cIncludes urine present in the bladder at study termination

^dIncludes contents