Table 7.

Disposition of [¹⁴C]choline in male and female Wistar Han rats 24 h following a single gavage (160 mg/kg) or IV (16 mg/kg) administration with or without DMAE pre-treatment.

	% Dose Recovereda
DMAE dose (mg/kg)	0	100	500	100(3)b	0	100	500	0	0
Tissue	Male, Gavage 160 mg/kg	Male, Gavage 160 mg/kg	Male, Gavage 160 mg/kg	Male, Gavage 160 mg/kg	Female, Gavage 160 mg/kg	Female, Gavage 160 mg/kg	Female, Gavage 160 mg/kg	Male, IV 16 mg/kg	Female, IV 16 mg/kg
Urinec	32.6 ± 2.30	31.9 ± 4.60	40.7 ± 6.30	39.9 ± 3.80	34.2 ± 7.90	34.7 ± 5.70	43.3 ± 5.60	3.92 ± 0.850	7.45 ± 2.58
Feces	21.5 ± 5.10	21.3 ± 13.8	11.2 ± 8.40	10.2 ± 10.2	12.9 ± 10.0	10.8 ± 6.00	2.52 ± 2.85	0.107 ± 0.052	0.303 ± 0.132
VOCs	0.123 ± 0.034	0.018 ± 0.003	0.065 ± 0.002	---	0.325 ± 0.025	0.268 ± 0.026	0.227 ± 0.057	0.139 ± 0.035	0.284 ± 0.038
CO2	12.5 ± 2.20	12.4 ± 1.70	15.1 ± 4.00	17.0 ± 1.70	17.8 ± 1.70	22.5 ± 4.40	22.4 ± 3.60	17.4 ± 2.40	28.1 ± 2.90
Tissues and GI Tractd	21.4 ± 2.80	20.4 ± 5.60	20.0 ± 3.80	26.6 ± 5.30	26.1 ± 3.80	24.7 ± 2.70	25.9 ± 4.70	56.2 ± 9.90	54.0 ± 5.50
Total Recovered	88.2 ± 5.50	86.1 ± 6.20	87.1 ± 1.90	93.7 ± 2.70	91.3 ± 9.60	92.9 ± 4.80	94.1 ± 4.80	77.7 ± 12.0	90.1 ± 6.10

^aMean ± SD for 3 animals

^bMales were administered three DMAE pre-treatments 48, 24, and 1 h prior to [¹⁴C]-choline administration.

^cIncludes urine present in the bladder at study termination

^dIncludes contents