Table 4.

Comparison of exposure multiples between rats^a and humans^b for selected terpene trilactones following ingestion of Ginkgo biloba extract

Rat doses		Exposure multiple (rat/human)c
mg GBE/kg	mg GBE/m2d	mg GBE/kg	mg GBE/m2	AUC
				BLLe	GLA	GLB
30	180	9	1.4	10	3	1
100	600	30	5	22	8	3
300	1800	88	14	59	20	7

^aData used was from the current study

^bData from Biber (2003) following ingestion of 240 mg EGB761® in adults was used. Assuming a 70 kg body weight, this corresponds to 3.4 mg/kg b.wt or 126 mg/m², using a K_m value of 37 for humans (Reagan-Shaw et al., 2008). AUC values reported in this study for BLL, GLA, and GLB, respectively, were: 247.1, 211.1, and 140.69 h*ng/mL (or 14826, 12666 and 8441 min*ng/mL)

^cRat/human exposure multiple was estimated 3 ways: mg/kg, mg/m² and AUC

^dDose in mg/m² was estimated by multiplying mg/kg by a K_m value of 6 for rats (Reagan-Shaw et al, 2008)

^eBLL, bilobalide; GLA, ginkgolide A; GLB, ginkgolide B