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. 2020 May 20;8(1):e000204. doi: 10.1136/jitc-2019-000204

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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Forest plots on association between protein plasma levels and progression-free survival (PFS), Cox models. High-resolution isoelectric focusing liquid chromatography–mass spectrometry (HiRIEF LC-MS/MS) data, levels pre-trm (A) and log2-fold change (log2-FC) (D); Proximity extension assays (PEAs) data, levels pre-treatment (pre-trm) (univariate analyses—B, multivariate—C) and log2-fold change (E). Dots = β estimate=log2 of HR, interval bars=95% CI of the β estimate. The β in HiRIEF LC-MS/MS data is underestimated (see section on Cox models in Additional File 1). HiRIEF data included only patients with anti-programmed cell death protein 1 (anti-PD-1) treatment, whereas PEA data included patients treated with anti-PD-1 and/or anti-cytotoxic T-lymphocyte–associated antigen 4.