Figure 7. CIC represses VGF through tethering mSWI/SNF-SIN3 complex.

(A) ChIP tracks on CIC transcription targets. (B) ChIP-qPCR results from NT^KD NPC and Cic^KD NPC at Vgf promoter region. Mean ± SEM of 3 experiments. (C) qPCR results of Etv4 and Etv5 mRNA expressions in NT^KD NPC and Cic^KD NPC at day 0 (D0) and D3 of differentiation. Mean ± SEM of 3 experiments. (D) qPCR results of Etv4 and Etv5 mRNA expressions in NT^KD NPC and Brg1^KD NPC. Mean ± SEM of 3 experiments. Statistical significance was determined by unpaired t test for B and 1-way ANOVA for C and D. **P < 0.01, *** P < 0.001. (E) The model schema for transcriptional regulatory mechanism by CIC-mSWI/SNF-SIN3 complex.