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. 2020 May 7;5(9):e135031. doi: 10.1172/jci.insight.135031

Figure 6. mTORC1 signaling is enriched and associated with type I IFN response gene expression in classical monocytes from iMCD flare.

Figure 6

(A and B) Enrichment of HALLMARK_MTORC1_SIGNALING in classical monocytes (A) and nonclassical monocytes (B). (C and D) Dot plots with linear regression of the average expression of genes from the HALLMARK_MTORC1_SIGNALING gene set and average expression of genes from the HALLMARK_INTERFERON_ALPHA_RESPONSE gene set within each single-cell sequenced from TAFRO-1, TAFRO-2, and TAFRO-3, identified as classical monocytes (C) and nonclassical monocytes (D). Linear regression was used to assess association between 2 continuous variables, and significant association was set if the lower 95% of the CI was above zero.