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. 2020 May 7;5(9):e136687. doi: 10.1172/jci.insight.136687

Figure 2. mC26 induces muscle atrophy and weakness.

Figure 2

(A) Muscle weights normalized to initial body weight (IBW) in CD2F1 male mice (12 weeks old) intrasplenically injected with C26 tumor cells (250,000 cells/mouse in sterile PBS, mC26) or an equal volume of vehicle (Sham) (n = 5). (B) Weekly whole body grip strength assessment (expressed in grams). (C) Cross-sectional area (CSA) of entire tibialis anterior muscles and representative CSA image of tibialis anterior muscle sections stained with anti-dystrophin antibody. Scale bars: 100 μm. Data are expressed as mean ± SD. Two-tailed t tests were used to determine differences between Sham and mC26. *P < 0.05, **P < 0.01 versus Sham.