Figure 5.

Expression of dominant‐negative Alk in neurons decreases night activity, increases night sleep and improves night sleep consolidation. (a) Activity traces and (b) quantification of day and night activity counts from mated female flies at 15 days of age showed significantly decreased night activity for w^Dah;;UAS‐Alk^DN/elav‐GS³⁰¹ flies treated with RU‐486 (200 μM) from 2 days of age compared to sibling flies of the same genotype treated with vehicle control food. (c) Sleep traces, (d) quantification of day and night sleep, and (e) quantification of the number of day and night sleep bouts from mated female flies at 15 days of age showed significantly increased night sleep and significantly decreased numbers of night sleep bouts for w^Dah;;UAS‐Alk^DN/elav‐GS³⁰¹ flies treated with RU‐486 (200 μM) from 2 days of age compared to sibling flies of the same genotype treated with vehicle control food. n = 32 individual flies per condition; p values are from Mann–Whitney tests vs. the vehicle‐treated (uninduced) group