. Author manuscript; available in PMC: 2020 Dec 19.

Published in final edited form as: Cell Chem Biol. 2019 Oct 31;26(12):1703–1715.e37. doi: 10.1016/j.chembiol.2019.10.005

Table 1. Pharmacokinetic parameters for compound 1 vs Prostetin/12k administered by IP injection or by OG.

Error is ± standard error of the mean (SEM).

Parameter	Cmpd 1, IP	Cmpd 1, OG	Prostetin/12k, IP	Prostetin/12k, OG
Plasma AUC (μg/L•h)	7328 (±1000)	3401 (±908.8)	3899 (±539.3)	2785 (±797.0)
Brain AUC (μg/L•h)	1568 (±147.1)	567.2 (±110.5)	11570 (±1655)	8429 (±1458)
Plasma mean C_max (μg/L)	971.7 (±138.2)	476.2 (±165.3)	454.0 (±48.62)	184.1 (±57.26)
Brain mean C_max (μg/kg)	208.8 (±10.21)	83.35 (±21.40)	1162 (±91.99)	658.9 (±257.7)
Mean brain/plasma ratio at 3h	0.23 (±0.014)	0.19 (±0.019)	3.0 (±0.59)	3.3 (±0.53)