Table 3:

Comparison of the mean (SD) in vitro aerosol drug delivery using the original delivery system and the updated version, with two new cannula designs, using steady state inhalation conditions. Values are reported as a percentage of nominal dose loaded into the capsule. Standard deviations (SD) shown in parenthesis [n=3].

Description	Original	Cannula 1	Cannula 2
Capsule (%)	13.9 (7.5)	12.8 (1.1)	8.6 (0.5)
Device (%)	2.4 (0.2)	2.3 (0.8)	1.6 (0.4)
Device ED (%)	83.7 (7.4)	85.2 (1.2)	89.8 (0.2)
Spacer (%)	6.6 (0.9)	6.4 (0.4)	6.4 (0.8)
Y Retention (%)*	4.5 (1.1)	0.5 (0.2)**	0.5 (0.1)**
Tubing Retention (%)	5.8 (0.8)	4.1 (0.9)	4.0 (0.8)
Cannula Retention (%)	4.9 (2.1)	5.0 (1.6)	4.1 (1.2)
Cannula ED (%)*	61.9 (2.8)	69.3 (2.7)**	74.7 (3.0)**
NMT (%)	4.6 (1.5)	7.3 (2.9)	6.9 (2.0)
Filter Delivery (%)	50.9 (3.0)	54.6 (8.5)	61.6 (4.8)
Recovery (%)	93.6 (1.2)	92.6 (3.6)	93.8 (0.7)

^*p<0.05 significant effect of system design on Y Retention and Cannula ED (one-way ANOVA).

^**p<0.05 significant difference compared to Original (post-hoc Tukey).