Table 4:
Comparison of mean (SD) in vitro aerosol drug delivery using steady state performance and realistic inhalation conditions with the revised delivery system and Cannula 2. Values are reported as a percentage of nominal dose loaded into the capsule. Standard deviations (SD) shown in parenthesis [n=3].
| Description | Steady State | Deep Nasal | Passive Nasal |
|---|---|---|---|
| Capsule (%) | 8.6 (0.5) | 11.1 (2.6) | 9.5 (2.5) |
| Device (%) | 1.6 (0.4) | 1.7 (0.4) | 1.7 (0.6) |
| Device ED (%) | 89.8 (0.2) | 87.2 (2.9) | 88.8 (2.9) |
| Spacer (%) | 6.4 (0.8) | 7.4 (2.2) | 7.3 (1.6) |
| Y Retention (%) | 0.5 (0.1) | 0.7 (0.3) | 0.7 (0.3) |
| Tubing Retention (%) | 4.0 (0.8) | 5.0 (1.8) | 4.9 (1.4) |
| Cannula Retention (%) | 4.1 (1.2) | 4.7 (1.9) | 4.6 (1.5) |
| Cannula ED (%) | 74.7 (3.0) | 69.3 (4.2) | 71.4 (1.9) |
| NMT (%) | 6.9 (2.0) | 8.9 (3.1) | 6.2 (2.1) |
| Filter Delivery (%) | 61.6 (4.8) | 53.4 (6.2) | 55.3 (4.1) |
| Recovery (%)* | 93.8 (0.7) | 92.9 (1.2) | 90.2 (0.3)** |
*
p<0.05 significant effect of system design on Recovery (one-way ANOVA).
**
p<0.05 significant difference compared to Steady State (post-hoc Tukey).