FIGURE 2.

Tau oligomer‐induced human induced pluripotent stem cell‐cortical neuron electrophysiological dysfunction. Application of tau oligomers (tau‐O) at 100 nM (final concentration) led to altered physiology in neurons (22‐28 DIV) after 24 hour of treatment. In particular, a pronounced decrease in current, induced repetitive firing under depolarization, and spontaneous firing (A) was observed. Moreover, quantitative analysis revealed a significant reduction in peak inward current (A‐i, B), a sharp decrease in the firing frequency of action potentials (A‐ii, C), and spontaneous activity (A‐i, D) in the samples treated with tau oligomers compared to controls (ie, untreated and tau‐BC). Statistical analysis was computed using student's t‐test. Error bars represent standard error of the mean and P ≤.05 is considered statistically significant