FIGURE 4.

Effects of tau oligomers on long‐term potentiation (LTP) maintenance in cortical neurons (A). The LTP induction protocol increased hiPSC‐derived cortical neuron spontaneous firing frequency on microelectrode arrays (MEAs; 14‐21 DIV) (B), this increase in LTP was maintained at 1 hour post‐dosing in the samples treated with the buffer control solution, whereas LTP was completely abolished by 1 hour of tau oligomer dosing (C). Representative MEA measured action potential traces and firing frequency bar graphs showed an increase in LTP after LTP induction and no significant changes in the samples dosed with the buffer control whereas tau oligomer dosing led to a significant reduction in LTP after 1 hour of dosing (A). Error bars represent standard error of the mean and alpha level was set at P ≤.05