Table 2. SNPs of microcephaly-related genes that are hypothesized to be associated with lexical tone perception.
Information for the alleles is obtained from the latest dbSNP database published by the National Center for Biotechnology Information (United States) for East Asians or based on our current sample.
| Gene | SNP | Population | Phenotype |
Allele frequency in dbSNP database |
Allele frequency in our sample |
N of cases for each genotype in our sample |
Total N of cases |
References | ||
| MCPH1 | rs1057090 | Han Chinese | Cranial volume |
T = 0.672; C = 0.328 |
T = 0.698; C = 0.302 |
TT = 210 | TC = 172 | CC = 42 | 424 | (26) |
| MCPH1 | rs11779303 | European (Norwegian) |
Cortical area |
G = 0.966; C = 0.034 |
G = 0.960; C = 0.040 |
GG = 390 | GC = 34 | CC = 0 | 424 | (25) |
| MCPH1 | rs930557 | European (Norwegian) |
Pitch perception |
C = 0.764; G = 0.236 |
C = 0.754; G = 0.246 |
CC = 240 | CG = 159 | GG = 25 | 424 | (3, 23) |
| MCPH1 | rs2816517 | European (Norwegian) |
Brain volume |
C = 0.824; A = 0.176 |
C = 0.800; A = 0.200 |
CC = 277 | CA = 124 | AA = 23 | 424 | (25) |
| ASPM | rs41310927 | European (Norwegian) |
Pitch perception |
T = 0.836; C = 0.164 |
T = 0.838; C = 0.162 |
TT = 299 | TC = 113 | CC = 12 | 424 | (3, 23) |
| CDK5RAP2 | rs1888893 | European (Norwegian) |
Cortical area |
A = 0.855; G = 0.145 |
A = 0.863; G = 0.137 |
AA = 310 | AG = 96 | GG = 9 | 415 | (25) |
| CDK5RAP2 | rs4836819 | European (Norwegian) |
Cortical area |
G = 0.818; A = 0.182 |
G = 0.808; A = 0.192 |
GG = 275 | GA = 135 | AA = 14 | 424 | (25) |
| CDK5RAP2 | rs7859743 | European (Norwegian) |
Cortical area |
G = 0.815; A = 0.185 |
G = 0.807; A = 0.193 |
GG = 273 | GA = 138 | AA = 13 | 424 | (25) |
| CDK5RAP2 | rs914592 | European (Norwegian) |
Cortical area |
A = 0.897; G = 0.103 |
A = 0.871; G = 0.129 |
AA = 323 | AG = 93 | GG = 8 | 424 | (25) |