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. 2020 Apr 2;9:e54558. doi: 10.7554/eLife.54558

Appendix 4—figure 4. Correlation between the odds of HCV clearance associated with an allele and the odds associated with similar alleles.

Appendix 4—figure 4.

The odds of spontaneous clearance of HCV associated with an HLA class I allele (“Coefficient of Index Allele", x axis) was correlated with the coefficient of HLA class I alleles with similar TCR binding (A), similar iKIR binding (B), similar activating KIR binding (C), similar LILRB1 binding (D) and similar LILRB2 binding (E). All alleles in the cohort of a sufficient frequency (N > 15) and with sufficient near alleles (N > 15 with 50% or more similarity) were considered. The Spearman correlation coefficient (Rs) and corresponding P value are reported in the title bar for each plot. Unlike HTLV-1 infection, and more in line with expectation, the picture was mixed with no single interaction able to explain all HLA associations. The strongest positive correlation was seen for alleles with similar TCR binding but the correlation is weak and not significant indicating that although the protection conferred by some alleles is attributable to TCR binding there are many alleles where the protection is better explained by another interaction.

Appendix 4—figure 4—source data 1. Data underlying Appendix 4—figure 4A.
Appendix 4—figure 4—source data 2. Data underlying Appendix 4—figure 4B.
Appendix 4—figure 4—source data 3. Data underlying Appendix 4—figure 4C.
Appendix 4—figure 4—source data 4. Data underlying Appendix 4—figure 4D.
Appendix 4—figure 4—source data 5. Data underlying Appendix 4—figure 4E.