Appendix 3—table 3. Interactions underlying HLA class I associations with disease progression in HIV-1 infection.
We investigated the interactions underlying HLA class I alleles which were significantly associated with disease progression in HIV-1 infection. HLA-B*53:01 was not included in this analysis as, in this cohort, it has no impact on progression to low CD4+ cell count (HR = 0.9, p=0.7).
| Index allele | |||||||
|---|---|---|---|---|---|---|---|
| Model | COV. | B*57:01 | B*57:02 | B*57:03 | |||
| 1. Index only |
index | HR | / | 0.40 | 0.50 | ||
| P val | / | 0.07 · |
0.04 * |
||||
| 2. Index+TCR.FS |
Index | HR | / | 0.40 | 0.49 | ||
| P val | / | 0.07 | 0.04 * |
||||
| TCR.FS | HR | 0.79 | 0.79 | 0.92 | |||
| P val | 0.33 | 0.5 | 0.8 | ||||
| 3. Index+iKIR.FS |
Index | HR | / | 0.40 | 0.50 | ||
| P val | / | 0.07 · |
0.04 * |
||||
| iKIR.FS | HR | 0.97 | 1.01 | ||||
| P val | 0.87 | 0.97 | |||||
| 4. Index+aKIR.FS |
Index | HR | / | 0.41 | 0.51 | ||
| P val | / | 0.08 · |
0.05 * |
||||
| aKIR.FS | HR | 0.60 | 0.61 | 0.61 | |||
| P val | 0.098 · |
0.17 | 0.16 | ||||
| 5. Index+LILRB1.S |
Index | HR | / | 0.35 | 0.39 | ||
| P val | / | 0.04 * |
0.006 ** |
||||
| LILRB1.S | HR | 0.83 | 0.19 | 0.004 | |||
| P val | 0.67 | 0.06 · |
0.0001 *** |
||||
| 6. Index+LILRB2.S |
Index | HR | / | 0.40 | 0.49 | ||
| P val | / | 0.07 · |
0.04 * |
||||
| LILRB2.S | HR | 0.95 | 0.92 | 0.79 | |||
| P val | 0.90 | 0.90 | 0.76 | ||||