Appendix 3—table 4. Impact on log10 viral load associated with different aKIR.FS groupings.

Investigation of individuals with similar aKIR binding to HLA*B57:01 revealed three distinct grouping (Figure 3A) which we named I, II and III. In a multivariate linear model to predict log10(viral load) these three different groupings (treated as three levels of a factor) had different coefficients, with only group I being significantly protective (top 3 rows of table below). Pooling groups II and III to increase the number of individuals in this grouping did not change the conclusion that only group I had a significant protective effect (bottom two rows of table below). Comparisons are with respect to the baseline (KIR3DS1:Bw4-80I- individuals, N = 438). In all cases gender was also included as a covariate in the model.

	Coefficient	P value	N in group
Group I	−0.38	0.007 **	47
Group II	−0.16	0.45	19
Group III	+0.05	0.78	20
Group I	−0.38	0.007 **	47
Group II+III	−0.04	0.76	39