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Video shows the starting conformation of QQQ, with residues Glnex, Glnin, and E113Q shown as sticks. The same residues in the WT structure are then shown for comparison, along with the side-chain conformational changes that occur in the MD simulation to allow formation of water pathways from the intracellular side. The water pathway shown corresponds to Cluster 1 in Figure 8—figure supplement 1D.
