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. 2020 Apr 23;40(6):1559–1573. doi: 10.1161/ATVBAHA.120.314297

Figure 1.

Figure 1.

EP4 (prostaglandin E receptor 4) overexpression in vascular smooth muscle cells promoted dissecting abdominal aortic aneurysm and rupture after Ang II (angiotensin II) infusion. A, Representative images of aortas of nontransgenic (non-Tg) and EP4-Tg before and after Ang II infusion. Scale bars=5 mm. B, Elastica van Gieson–stained sections of the abdominal aortas of non-Tg and EP4-Tg mice after Ang II infusion. Lower stained sections (scale bars=20 μm) are magnifications of the upper stained sections (scale bars=500 μm). C and D, Maximum aortic diameter and elastin degradation grade of the aortas of non-Tg and EP4-Tg mice infused with Ang II. n=5 to 8. E, Survival rates of non-Tg and EP4-Tg mice after Ang II infusion. n=8 to 10. NS indicates not significant. *P<0.05, **P<0.01, ***P<0.001.