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. 2020 Mar 24;175(2):168–181. doi: 10.1093/toxsci/kfaa041

Figure 1.

Figure 1.

Exogenous netrin-1 attenuated acetaminophen (APAP)-induced liver injury. Fasted C57BL/6J mice were treated with either APAP (300 mg/kg) alone, APAP+netrin-1 (1 µg/mouse), or saline as controls after overnight fasting. Blood and liver tissues were obtained at 6, 12, and 24-h post-APAP. A, Plasma alanine aminotransferase activity. B, Hematoxylin and eosin staining of representative liver sections (×50 magnification). C, Plasma levels of netrin-1, 24 h after APAP or APAP+netrin-1 compared with controls. D, DNA fragmentation measured by the TUNEL assay (×50 magnification). Data represent means ± SE of n = 3–10 animals per group. *p < .05 (compared with control). #p < .05 (compared with APAP 24 h group). $p < .05 (compared with APAP group).