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. 2020 Mar 19;175(2):182–196. doi: 10.1093/toxsci/kfaa040

Figure 4.

Figure 4.

Maternal cypermethrin and stress altered microglia morphology in the E14 dorsal forebrain. A, Representative pictures of E14 microglia morphologies: (1) Multivacuolated, with multiple vacuoles and/or pyknotic nuclei, (2) Ameboid, with no processes and normal nucleus, (3) Transitional, with 1 process and normal nucleus, (4) Ramified, with 2 or more processes and normal nuclei (high magnification). Representative picture of the forebrain stained for Iba1 to the right (low magnification). B, Cypermethrin increased percentage of ameboid microglia. C, No effect for either treatment on transitional microglia. D, Cypermethrin decreased the percentage of ramified microglia. E, Cypermethrin alone, but not in combination with stress, increased the percentage of multivacuolated microglia. F, No effect for either treatment on total microglia density. Means ± SEMs are shown. n = 5–7 litters per treatment group (**p < .01 by post hoc tests) (#p < .05, ##p < .01 main effect by 2-way ANOVA) (^p < .05 interaction by 2-way ANOVA). Abbreviations: NS, nonstressed; PS, prenatal stress.