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. 2020 Mar 19;175(2):182–196. doi: 10.1093/toxsci/kfaa040

Figure 5.

Figure 5.

Maternal stress increased concentration of cypermethrin in maternal serum and altered maternal hepatic expression of cytochrome P450 enzymes after cypermethrin exposure. A, Restraint stress increased the concentration of cypermethrin in maternal serum. B, Cypermethrin levels in amniotic fluid were below the limit of quantification. C, Stress suppressed cypermethrin-dependent upregulation of hepatic Cyp1a1 expression. D, Stress reduced hepatic expression of Cyp1a2. E, Stress reduced hepatic expression of Cyp2b10. F–H, Stress or cypermethrin did not affect hepatic expression of Cyp2e1, Cyp3a11, or Cyp3a41b. Means ± SEMs are shown. n = 5–7 litters per treatment group (*p < .05 by Mann-Whitney or post hoc tests) (#p < .05, ##p < .01 main effect by 2-way ANOVA) (^p < .05 interaction by 2-way ANOVA). Abbreviations: NS, nonstressed; PS, prenatal stress.