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Microscopic observation of changes in AQP3 expression on days 3 and 8 after injection. The increase in AQP3 expression in the epidermis (basal layer of keratinocyte) is shown as an enhanced intensity of immunostaining (pink). AQP3, aquaporin-3; HYD, noncrosslinked hyaluronic acid with mannitol; VYC-12L, crosslinked hyaluronic acid injectable gel with lidocaine.
