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Microscopic observation of changes in GAG content on days 3 and 8 after injection. The increase in acidic GAG expression in the papillary dermis and upper reticular dermis is shown as an enhanced intensity of blue staining. GAG, glycosaminoglican; HYD, noncrosslinked hyaluronic acid with mannitol; VYC-12L, crosslinked hyaluronic acid injectable gel with lidocaine.
