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Point mutations on chromosomal genes conferring colistin resistance in the E. hormaechei isolates from South Africa
| Isolatea | MIC (μg/ml) | Mutation(s) in: |
||||
|---|---|---|---|---|---|---|
| pmrB | pmrA | phoP | phoQ | mgrB | ||
| EC001 | ≤2 | S175N, T210S, I227L, A233T, A344T | None | None | None | M1V |
| EC009 | ≤2 | |||||
| EC010 | >4 | |||||
| EC015 | >4 | |||||
| K006 | ≤2 | T121A, I134V, A344T | ||||
| K063 | >4 | |||||
| K130 | ≤2 | |||||
| PM005 | >4 | —b | — | — | — | — |
The reference genome used was Enterobacter hormaechei strain C15117 (PRJNA494598).
—, intrinsic resistance.
