Table 1.

Examples of prenyltransferases and their substrates

Enzyme	Organism	Prenyl acceptor (examples)	Prenyl donor	References
ABBA-type PTases
CloQ	Streptomyces roseochromogenes	4-HPP, flavonoids, isoflavonoids, stilbenoid	DMAPP	[46]
NovQ	Streptomyces spheroids	Phenylpropanoids, flavonoids, DHNs	DMAPP	[45]
NphB	Streptomyces sp. CL190	4-HPP, plant polyketides, DHNs	GPP	[24, 38, 47]
Fnq26	Streptomyces cinnamonensis DSM 1042	DHNs, flavolin, 4-hydroxybenzoic acid	GPP	[43]
SCO7190	Streptomyces coelicolor A3	Plant polyketids, DHNs	DMAPP	[24, 38, 47]
XptB	Aspergillus nidulans	Xanthone	DMAPP	[48]
VrtC	Penicillium aethiapicum	Tetracycline-like naphthacenediones	DMAPP, GPP	[49]
PaPT	Phomopsis amygdali	Fusicoccin P		[50]
TleC	Streptomyces blastmyceticus	Indolactam V	DMAPP, GPP, FPP	[83–87]
MpnD	Marinactinospora thermotolerans	Indolactam V	DMAPP, GPP, FPP, GGPP, GFPP	[83–87]
AtaPT	Aspergillus terreus	Lignanoids, xanthones, quinoline alkaloids, coumarins, benzophenones, curcuminoid, hydroxynaphthalenes	DMAPP, GPP, FPP, GGPP, PPP	[88]
Cyanobactin PTases
LynF	Lyngbya aestuarii	Tyr residue in cyclic peptides, N-boc-tyrosine	DMAPP	[51]
PagF	Oscillatoria agardhii	L-Tyr, N-acetyl-L-Tyr, N-boc-L-Tyr, Tyr-Tyr-Tyr, Tyr4 residue in cyclic[INPYLYP]	DMAPP	[59]
TruF		Ser and Thr residues in cyclic peptides	DMAPP	[52, 57, 62]
KgpF	Microcystis aeruginosa NIES-88	Trp residue in kawaguchipeptine B, Fmoc-Trp	DMAPP	[58]
TyrPT	Aspergillus niger	Tyr and Trp derivatives	DMAPP, alkyl-PPs	[31, 63]
SirD	Leptosphaeria maculans	Tyr and Trp derivatives	DMAPP, alkyl-PPs	[29, 31, 41, 63, 92]
DMAT-type PTases
5-DMAT	Aspergillus clavatus, Streptomyces coelicolor	Tyr and Trp derivatives, indolocarbazoles	DMAPP, alkyl-PPs	[63, 70, 89]
6-DMAT	Streptomyces ambofaciens, Streptomyces violaceusniger, Streptomyces sp. SN-593	Tyr and Trp derivatives, naphthalene derivatives	DMAPP, GPP, alkyl-PPs	[63, 72, 73]
7-DMAT	Aspergillus fumigatus, Neosartorya sp.	Tyr and Trp derivative, naphthalene derivatives, acylphloroglucinols, flavonoids	DMAPP, alkyl-PPs	[44, 63, 66]
AnaPT	Neosartorya fischeri	Tyr and Trp derivative, Trp-containing cyclic dipeptides, acylphloroglucinols, flavonoids	DMAPP, alkyl-PPs	[44, 67, 82, 91]
FgaPT2	Aspergillus fumigatus	Tyr and Trp derivatives, Trp-containing cyclic dipeptides, indolocarbazoles	DMAPP, alkyl-PPs	[26, 36, 42, 63, 90, 93]
CdpC3PT	Neosartorya fischeri	Trp-containing cyclic dipeptides, acylphloroglucinols	DMAPP, alkyl-PPs	[67, 77, 91]
CdpNPT	Aspergillus fumigatus	Trp-containing cyclic dipeptides, naphthalene derivatives	DMAPP, alkyl-PPs	[37, 67, 79, 91]
BrePT	Aspergillus versicolor	Trp-containing cyclic dipeptides	DMAPP, alkyl-PPs	[30, 91]
FtmPT1	Aspergillus fumigatus	Trp-containing cyclic dipeptides, indolylbutenone	DMAPP, alkyl-PPs	[27, 28, 91]