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. 2020 Apr 29;57(6):2741–2765. doi: 10.1007/s12035-020-01913-6

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© The Author(s) 2020

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Fig. 1 — Schematic representation of the two α-Syn oligomeric polymorphs. a Generation of α-Syn oligomers by dopamine (DA) modification. Dopamine gets readily oxidized into its quinones, which are then thought to interact with α-Syn by both covalently and non-covalently forming adducts. These adducts result in the formation of modified α-Syn oligomers, hence termed as SynO-DA. b Generation of α-Syn oligomers modified by docosahexaenoic acid (DHA), termed as SynO-DHA, primarily via covalent bonding