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. 2020 May 27;3:270. doi: 10.1038/s42003-020-0994-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Intestinal Cav-1 expression was compared in patients with different IBD types in datasets gse117993 (Denson's, n = 190) and gse75214 (Vemeire's, n = 194). b Colonic Cav-1 protein expression was compared in patients with different IBD types in a proteomic dataset (PXD005086, n = 99). c Intestinal Cav-1 expression was compared in DSS-exposed mice using the dataset (gse22307, n = 6-7). a–c Results are shown as box-and-whisker plots (min to max) and asterisks (*) indicate significant differences from the control group (*p < 0.05, **p < 0.01, ***p < 0.001 using two-tailed unpaired Student’s t test). d, e Cav-1 expression was assessed in colons from 8-week-old female C57BL/6 mice treated with vehicle or 3% (w/v) DSS (n = 14–15, each group). Microscopic analysis was conducted at 200× magnification; scale bar(s): 100 μm. d Relative Cav-1 density was measured using the HistoQuest tissue analysis software (each histogram represents events with increasing DAB levels, as denoted in the method in detail). e Quantitative comparisons are shown in the graph. Asterisks (***) indicate a significant difference from the control group (p < 0.001 using two-tailed unpaired Student’s t test). f, g Intestinal expression of eIF2a kinases (EIF2AK1, EIF2AK2, EIF2AK3, or EIF2AK4) or Cav-1 was compared in patients with different IBD types from datasets gse117993 (e, Denson’s, n = 190) and gse75214 (f, Vemeire’s, n = 194). UC, ulcerative colitis; cCD, colon-only CD; iCD, ileo-colonic CD. Results are shown as box-and-whisker plots (min to max). Asterisks (*) indicate significant differences between groups (*p < 0.05, **p < 0.01, ***p < 0.001 using two-tailed unpaired Student’s t test). h, i Expression levels of PKR target genes were assessed in patients with IBD (gse75214 [n = 194] or gse117993 [n = 190]). Based on PKR levels, we chose the 50 highest and 50 lowest samples, which were further compared for expression of ISR-linked genes (ATF4 and CHOP) (h), or Cav-1 (i). Results are shown as box-and-whisker plots (min to max). Asterisks (*) indicate significant differences from the low-expression group (**p < 0.01, ***p < 0.001 using two-tailed unpaired Student’s t test).