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. 2020 Jan 13;29(6):1533–1547. doi: 10.1007/s11136-019-02412-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/

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Fig. 2 — HRQoL according to VOC frequency (a) and severity (b). HRQoL scores differ as a function of VOC frequency/severity for all domains (P < 0.05). Higher ASCQ-Me impact scores indicate better functioning. Less severe VOCs = ASCQ-Me Pain Episode Severity score < 55; more severe VOCs = ASCQ-Me Pain Episode Severity score ≥ 55. ASCQ-Me Adult Sickle Cell Quality of Life Measurement Information System, HRQoL health-related quality of life, SCD sickle cell disease, VOCs vaso-occlusive crises