Table 4.

HRQoL according to VOC frequency

ASCQ-Me domaina	0–3 VOCs in the past 12 months					≥ 4 VOCs in the past 12 months					Pb
	N	Mean	SD	Median	IQR	N	Mean	SD	Median	IQR
Emotional impact	160	48.16	8.33	47.40	42.50–54.25	143	44.80	7.23	44.90	39.90–48.70	0.001
Social functioning impact	160	49.92	9.48	48.80	43.90–55.80	143	43.73	7.71	43.90	38.70–48.80	< 0.001
Stiffness impact	160	48.20	8.72	48.10	42.70–52.70	143	44.67	7.52	45.40	39.90–49.50	0.001
Sleep impact	160	49.87	6.65	49.70	45.00–55.30	143	47.42	6.19	46.70	43.20–51.10	< 0.001
Pain impact	160	50.06	9.49	48.50	44.40–58.00	143	45.41	8.89	45.70	38.30–51.20	< 0.001

ASCQ-Me Adult Sickle Cell Quality of Life Measurement Information System, VOCs vaso-occlusive crises, SD standard deviation, IQR inter-quartile range, HRQoL Health-related quality of life

^aHigher ASCQ-Me impact scores indicate better functioning

^bAfter Bonferroni correction, all associations remained statistically significant, with P < the Bonferroni correction-adjusted critical value of 0.01