Table 5.

HRQoL according to VOC severity

ASCQ-Me domaina	Less severe VOCs					More severe VOCs					Pb
	N	Mean	SD	Median	IQR	N	Mean	SD	Median	IQR
Emotional impact	188	48.00	7.36	47.40	43.10–51.50	115	44.24	8.48	43.70	39.90–48.70	< 0.001
Social functioning impact	188	49.22	8.61	48.80	43.90–54.00	115	43.37	9.05	42.10	36.80–47.20	< 0.001
Stiffness impact	188	47.49	7.80	46.70	44.00–51.00	115	44.97	8.99	45.40	38.40–49.50	0.008
Sleep impact	188	49.52	6.58	49.70	45.00–53.90	115	47.40	6.29	46.70	43.20–51.10	0.005
Pain impact	188	49.16	8.93	47.10	44.40–55.80	115	45.75	10.00	44.40	38.30–51.20	0.002

More severe VOCs: ASCQ-Me Pain Episode Severity score ≥ 55 (½ SD worse than the benchmark score); less severe VOCs: ASCQ-Me Pain Episode Severity score < 55

ASCQ-Me Adult Sickle Cell Quality of Life Measurement Information System, VOCs vaso-occlusive crises, SD standard deviation, IQR inter-quartile range, HRQoL Health-related quality of life

^aHigher ASCQ-Me impact scores indicate better functioning

^bAfter Bonferroni correction, all associations remained statistically significant, with P < the Bonferroni correction-adjusted critical value of 0.01