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. 2020 May 21;14:132. doi: 10.3389/fncel.2020.00132

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Copyright © 2020 Gupta, Jadhav, Tan, Saw, Mallilankaraman and Dheen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-142-3p/5p upregulates in activated microglia and targets CAMK2A. (A) Histogram depicts a significant upregulation of miR-142-3p and miR-142-5p in activated microglia upon LPS treatment for 6 h. Data represented as mean ± SD, (n = 5), Students t-test, *p < 0.05. (B) Bioinformatics analysis predicted that miR-142-3p and miR-142-5p putatively target 3′UTR of Camk2a. The seed region and the target site type have been highlighted (TargetScan and Miranda software was used to predict miRNA targets. Image acquired from http://www.microrna.org/). (C) Histogram depicting a significant decrease in mRNA expression levels of Camk2a in activated microglia upon LPS treatment for 6 h, suggesting an inverse relationship between miR-142-3p/5p and its target gene, Camk2a. Data represented as mean ± SD, (n = 4), Students t-test, ***p < 0.001.