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Dysregulated miRNAs in the pathogenesis of MG based on antibody subtype. In acetylcholine receptor antibody seropositive (AChR+) MG, thymus hyperplasia is often found in young patients. miR-146, miR-612, miR-3651, and miR-3653 are upregulated, and miR-15b and miR-145 are downregulated. In muscle-specific tyrosine kinase antibody seropositive (MuSK+) MG, the thymus glands are relatively normal, and let-7a-5p, let-7f-5p, miR-151a-3p, miR-423-5p, and miR-1933-3p are upregulated.
