TABLE 1.

Summary of altered microRNAs (miRNAs) and their targeted cytokines in Myasthenia Gravis (MG).

MiRNAs	Immune cells type	Regulation	Target interleukin	Roles	References
miR-181a	Th1 cell	Down-regulated	IL-2↑	Modulate the activation of CD4+ T cells, expression of transcription factors related to Th1 and Th17 cells.	Liu et al. (2019)
miR-20b	Th1 cell	Down-regulated	IL-8↑, IL-25↑	Inhibit the expression of inflammatory cytokines.	Chunjie et al. (2015)
miR-320a	Th1 cell	Down-regulated	IL-2↑	miR-320a can regulate COX-2 expression through ERK/NF-κB pathways	Cheng et al. (2013)
miR-15b	Th1 cell	Down-regulated	IL-15↑	Regulates IL-15 expression by directly targeting its 3′-UTR	Shi et al. (2015)
let-7c	Th2 cell	Down-regulated	IL-10↑	Regulates IL-10 expression by directly targeting its 3′-UTR	Jiang et al. (2012)
miR-181c	Th17 cell	Down-regulated	IL-7↑, IL-17↑	Negatively regulate immune cell activation	Zhang et al. (2016)
miR-15a	Th17 cell	Down-regulated	IL-17↑, IFN-γ↑	Modulate CXCL10 to increase the expression of cytokines	Liu et al. (2016)
miR-145	B cells	Up-regulated	CD28↓	Play an important role in antigen specific T cells activation	Wang et al. (2013)
miR-146	B cells	Down-regulated	CD40↑, CD80↑	Modulate differentiation and function of cells in innate as well as adaptive immunity	Lu et al. (2013)