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. 2020 May 21;10:667. doi: 10.3389/fonc.2020.00667

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Copyright © 2020 Yan, Huang, Zhu, Cui, Li, Huang, Yan and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ten-eleven translocation 1 (TET1) was underexpressed in human urinary bladder cancer (UBC) tissues, and its low expression predicts poor prognosis in UBC patients. (A) The expression of TET1 protein in 24 pairs of UBC (T) and matched adjacent normal bladder tissues (N) by Western blotting. (B) TET1 protein expression levels by quantitation of densities of protein bands from Western blot in UBC tissues relative to the normal (n = 24, p = 0.0022) by ImageJ software. (C) Endogenous expression of TET1 in various human UBC cell lines and a nonmalignant normal urothelial cell line by Western blotting. (D) Immunohistochemical (IHC) staining of TET1 expression in a section containing cancerous (right insect) and its adjacent normal urothelial cells (left insect). Scale bar, 100 and 20 μm (inset). (E) The representative IHC images of TET1 and 5-hydroxymethylcytosine (5 hmC) expression in UBC tissues. (F) Kaplan–Meier analysis of the correlation between TET1 expression and overall survival (OS) in UBC patients through IHC score (n = 88). (G) The correlation of TET1 and 5 hmC expression in UBC tissues were analyzed by Pearson correlation coefficient analysis. The correlation coefficient and p-values are shown. Scale bar, 50 and 20 μm (inset).