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. 2020 May 21;10:667. doi: 10.3389/fonc.2020.00667

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Copyright © 2020 Yan, Huang, Zhu, Cui, Li, Huang, Yan and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of ten-eleven translocation 1 (TET1) facilitates urinary bladder cancer (UBC) cell proliferation and invasion. (A,B) The efficiency of knockdown of TET1 (A) and 5-hydroxymethylcytosine (5 hmC) level (B) in 5,637 cell line were confirmed by Western blotting and dot blot, respectively. (C–F) Effects of TET1 knockdown on cell proliferation (C), colony formation (D), migration (E), and invasion (F) of UBC cells. Scale bar, 200 μm (E) and 100 μm (F) **p < 0.01, ***p < 0.001.