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. 2020 May 21;11:439. doi: 10.3389/fphys.2020.00439

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Copyright © 2020 Lakatos, Jancsó, Horváth, Dobos and Sántha.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mustard oil-induced changes in blood flow of the dorsal hindpaw skin after transection and ligation of the saphenous nerve. Original perfusion images demonstrate mustard oil-induced vasodilatatory responses before (A), and 4 (B), 14 (C), 29 (D), and 40 (E) days after surgery. Note the gradual recovery of the vasodilatatory response in the medial aspect of the hindpaw. Image F illustrates the effect of the selective defunctionalization by perineural capsaicin treatment of sciatic afferents on the mustard oil-induced vasodilation. Note the marked reduction of the vasodilatatory response in both the lateral and the medial aspects of the dorsal hindpaw skin served by the sciatic and saphenous nerves, respectively, after capsaicin treatment. G: The histogram shows the quantitative data on changes in the vasodilatatory responses following saphenous nerve transection. Note the marked decrease shortly after transection and the gradual recovery over a period of 4–5 weeks, indicating denervation and reinnervation of the denervated saphenous skin area. H: Forty days after saphenous nerve transection and four days after perineural capsaicin treatment of the sciatic nerve significant reductions of mustard oil-induced vasodilatation in both the medial (filled column) and lateral (empty column) aspect of the dorsal hindpaw skin were detected as compared to the vasodilatatory response measured in the contralateral dorsal hindpaw skin (^∗p < 0.05; n = 8). Scale bar on A represents 5 mm.