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Close up of the endosomal trafficking from the PM toward TGN/EE. TOLs and SH3P2 fulfill ubiquitin recognizing functions at the PM, possibly guiding K63-linked ubiquitinated cargo to the endosomal membrane and interacting with/recruiting ESCRT-I subunits. At the endosomal membrane, the ESCRT-I binding FYVE1/FREE1 and ALIX also shows interaction with ubiquitin. This reveals the complex synergy of several possible ubiquitin receptors in the ESCRT-mediated degradation pathway.
