Table 2.
Procedural and clinical outcomes according to the treatment groups
| Outcomes | Endovascular treatment |
Center adjusted |
p value | Fully adjustedc |
p value | |
|---|---|---|---|---|---|---|
| Head-First | Neck-First | OR (95% CI) | OR (95% CI) | |||
| mTICI 2b/3 (successful reperfusion) | 79/107 (73.8) | 145/182 (79.7) | 1.31 (0.69–2.46) | 0.40 | 1.18 (0.60–2.17) | 0.68 |
| mTICI 3 (complete reperfusion) | 27/107 (25.3) | 75/182 (41.2) | 1.95 (1.12–3.38) | 0.017 | 1.68 (0.96–2.92) | 0.068 |
| Median puncture to successful reperfusion time (IQR), min | 56 (39–90) | 70 (50–102) | n.a. | 0.011a | n.a. | 0.001 |
| 90-day mRS score 0–2 | 51/104 (49.0) | 96/181 (53.0) | 1.17 (0.71–1.91) | 0.52 | 1.15 (0.68–1.93) | 0.59 |
| Any procedural complication(s)b | 19/102 (18.6) | 21/178 (11.8) | 0.70 (0.32–1.51) | 0.36 | 0.77 (0.34–1.67) | 0.49 |
| 90-day mortality | 18/104 (17.3) | 26/181 (14.4) | 0.80 (0.41–1.55) | 0.51 | 0.99 (0.49–1.99) | 0.97 |
| Any ICH | 43/107 (40.2) | 75/160 (46.9) | 1.02 (0.59–1.76) | 0.95 | 1.05 (0.61–1.82) | 0.85 |
| Parenchymal hematoma type 1/2 | 11/107 (10.3) | 27/160 (16.9) | 1.78 (0.79–3.99) | 0.16 | 2.28 (0.94–5.51) | 0.068 |
| Symptomatic ICH | 4/107 (3.7) | 11/150 (6.9) | 1.89 (0.53–6.78) | 0.33 | 2.41 (0.61–9.47) | 0.21 |
Values are expressed as n/total n (%), unless otherwise indicated. ORs were calculated using Head-First as the reference group. Bold values indicate significance. CI, confidence interval; mTICI, modified Thrombolysis in Cerebral Infarction; mRS, modified Rankin Scale; OR, odds ratio; ICH, intracerebral hemorrhage.
Calculated on log-transformed value.
Embolic new territory (n = 28), vessel perforation (n = 4), carotid dissections (n = 3), and other complications (n = 5).
Adjusted for center and baseline between-group differences (i.e., hypercholesterolemia, Alberta Stroke Program Early CT Score, and cervical internal carotid artery lesion [stenosis ≥90% vs. occlusion]) and calculated after handling missing data by multiple imputation (m = 10).