Table 3.
Sensitivity analysis excluding patients with complete cervical carotid occlusion
| Outcomes | Endovascular treatment |
Center adjusted |
Fully adjustedc |
|||
|---|---|---|---|---|---|---|
| Head-First | Neck-First | OR (95% CI) | p value | OR (95% CI) | p value | |
| mTICI 2b/3 (successful reperfusion) | 35/46 (76.1) | 99/117 (84.6) | 1.46 (0.59–3.63) | 0.41 | 1.23 (0.48–3.15) | 0.66 |
| mTICI 3 (complete reperfusion) | 13/46 (28.3) | 54/117 (46.2) | 2.18 (1.03–4.58) | 0.041 | 1.88 (0.86–3.98) | 0.11 |
| Median puncture to successful reperfusion time (IQR), min | 55 (31–93) | 71 (54–112) | n.a. | 0.030a | n.a. | 0.005 |
| 90-day mRS score 0–2 | 21/46 (45.7) | 63/117 (53.9) | 1.29 (0.63–2.63) | 0.48 | 1.09 (0.51–2.29) | 0.82 |
| Any procedural complication(s)b | 8/43 (18.6) | 11/116 (9.5) | 0.65 (0.21–1.97) | 0.45 | 0.77 (0.24–2.47) | 0.67 |
| 90-day mortality | 9/46 (19.6) | 16/117 (13.7) | 0.65 (0.26–1.61) | 0.35 | 0.90 (0.34–2.36) | 0.83 |
| Any ICH | 22/46 (47.8) | 56/107 (52.3) | 1.05 (0.51–2.18) | 0.89 | 1.13 (0.54–2.35) | 0.75 |
| Parenchymal hematoma type 1/2 | 2/46 (4.4) | 22/107 (20.6) | 5.69 (1.26–25.66) | 0.024 | 10.05 (1.99–50.68) | 0.005 |
| Symptomatic ICH | 1/46 (2.2) | 9/107 (8.4) | 3.85 (0.45–32.86) | 0.22 | 5.88 (0.62–55.57) | 0.12 |
Values expressed as n/total n (%), unless otherwise as indicated. Bold values indicate significance. CI, confidence interval; mTICI, modified Thrombolysis in Cerebral Infarction; mRS, modified Rankin Scale; OR, odds ratio; ICH, intracranial hemorrhage.
a
Calculated on log-transformed value.
b
Embolic new territory (n = 11), vessel perforation (n = 3), carotid dissections (n = 2), and other complications (n = 3).
c
Adjusted for center and baseline between-group differences (i.e., hypercholesterolemia and Alberta Stroke Program Early CT Score) and calculated after handling missing data by multiple imputation (m = 10).