Anatomical silicone model of ICA-MCA-ACA used for in vitro first pass effect study. The example shown is with fibrin-rich clot in MCA with SolitaireTM 6 × 40 mm deployed. The 088 sheath (in proximal ICA) is not shown. PCOM, posterior communicating artery; ACA, anterior cerebral artery; ICA, internal carotid artery; MCA, middle cerebral artery; DAC, distal access catheter.