Table 4.
Scoring results of lesion in the liver of control and all the treated groups of rats after 4 weeks of treatment with curcumin and Cur-CSCaCO3NP using Kruskal Wallis test for global comparison of organ lesions among all groups.
| Pathological parameters | Control | Cur 100 | Cur-CSCaCO3NP 50 | Cur-CSCaCO3NP 100 | Asymptomatic significant (p < value) |
|---|---|---|---|---|---|
| Activated Kupffer cells | 0.4 ± 0.24 | 1.3 ± 0.12* | 1.2 ± 0.12 | 1.1 + 0.1 | 0.0334 |
| Necrosis | 0.2 ± 0.2 | 1.4 ± 0.19* | 1.2 ± 0.12 | 1.1 ± 0.1 | 0.0128 |
| Vaculation (fatty changes) | 0.4 ± 0.24 | 1.6 ± 0.19* | 1.3 ± 0.2 | 1.1 ± 0.1 | 0.0159 |
| Inflammatory cell infiltration | 0.0 | 0.9 ± 0.24 | 0.8 ± 0.2 | 0.5 ± 0.32 | 0.0694 |
| Karyolysis | 0.2 ± 0.2 | 1.2 ± 0.2* | 0.9 ± 0.1 | 0.6 ± 0.24 | 0.0303 |
| Pyknosis | 0.2 ± 0.2 | 1.1 ± 0.1 | 0.7 ± 0.3 | 0.6 ± 0.24 | 0.0965 |
| Karyorrhexis | 0.0 | 0.4 ± 0.24 | 0.3 ± 0.3 | 0.2 ± 0.2 | 0.5401 |
The symbol * denotes the values were significantly different (p < 0.05) between all the treated groups and the control group. Values were presented as mean ± SEM, n = 5.