Table 6.
Scoring results of lesion in the kidney of control and all the treated groups of rats after 4 weeks of treatment with curcumin and Cur-CSCaCO3NP using Kruskal Wallis test for global comparison of organ lesions.
| Pathological parameters | Control | Cur 100 | Cur-CSCaCO3NP 50 | Cur-CSCaCO3NP 100 | Asymptomatic significant (p < 0.05) |
|---|---|---|---|---|---|
| Necrosis | 0.1 ± 0.1 | 1.1 ± 0.1* | 1.8 ± 0.12 | 0.7 ± 0.2 | 0.0077 |
| Tubular dilatation | 1 ± 0.31 | 1.6 ± 0.1 | 1.2 ± 0.12 | 1.1 ± 0.1 | 0.7071 |
| Inflammatory cell | 0.1 ± 0.1 | 0.8 ± 0.26 | 0.4 ± 0.19 | 0.2 ± 0.12 | 0.1118 |
| Eosinophilic cytoplasm | 0.3 ± 0.2 | 1 ± 0.16 | 0.8 ± 0.12 | 0.6 ± 0.1 | 0.0573 |
| Atrophy of glomerulus | 0.2 ± 0.1 | 1.1 ± 0.29 | 0.8 ± 0.26 | 0.5 ± 0.16 | 0.0677 |
| Fatty degeneration | 0.1 ± 0.1 | 1 ± 0.16* | 0.8 ± 0.16 | 0.5 ± 0.6 | 0.0126 |
The symbol * denotes the values were significantly different (p < 0.05) among all the treated groups and the control group. Values were presented as mean ± SEM, n = 5.