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. 2020 May 28;182(1):59–72.e15. doi: 10.1016/j.cell.2020.05.032

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© 2020 Elsevier Inc.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Figure S2 — Quality Control of Proteomic and Metabolomic Data, Related to Figure 1

(A) Coefficient of variation (CV) of the proteomic data is calculated by the proteins quantified in six quality control (QC) samples using the pooled samples from all samples in training cohort. CV of the metabolomic data is calculated by twelve QC samples using a set of isotopic internal spiked-in standards.

(B) Uniform Manifold Approximation and Projection (UMAP) of sera samples using 791 measured proteins in the training cohort.

(C) UMAP of sera samples using 847 metabolites excluding drugs.

(D) UMAP analysis of the COVID-19 patients using 791 measured proteins.

(E) UMAP analysis of the COVID-19 patients using 847 metabolites.

In D and E, patients labeled in red received serum test before they were diagnosed as severe. Inside the brackets are the sex, age, time from disease onset to admission and time from sampling to diagnose of severe case in sequence.