Table 2.
Antiviral activity and cytotoxicity of the four most potent drug compounds.
| Compound | CC50 (μM) (CellTiterGlo®)a |
EC90 (μM) (viral load reduction assay) |
EC50 (μM) (plaque reduction assay) |
Select index (CC50/EC50) |
|---|---|---|---|---|
| Cetilistat | >100.00 | 2.90 | 1.13 | >88.50 |
| Diiodohydroxyquinoline | >100.00 | 4.50 | 1.38 | >72.46 |
| Abiraterone (acetate) | 92.35 | 8.40 | 1.94 | 47.60 |
| Bexarotene | 38.21 | 9.40 | 2.01 | 19.01 |
Abbreviations: CC50, 50 % cytotoxic concentration; EC50, 50 % maximal effective concentration; EC90, 90 % maximal effective concentration.
a
>100 indicates the highest drug concentration tested in the cytotoxicity assay was 100μM.